Analysis Tools
neoplasm
preneoplasia
(
J:142030
)
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• after 3 weeks, mice treated with adenovirus cre via intranasal delivery and exposed to tamoxifen develop multiple hyperplastic and dysplastic epithelial foci with pseudotratification and occasional micropapillary tuft formation in the lungs unlike in similarly treated wild-type mice
• after 6 weeks, mice treated with adenovirus cre via intranasal delivery and exposed to tamoxifen exhibit extensive micropapillary and papillary hyperplasia with several bronchioles exhibiting Clara cell hyperplasia and sloughing into the airway lumen unlike similarly treated wild-type mice
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