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Phenotypes Associated with This Genotype
Genotype
MGI:3821753
Allelic
Composition		 Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre/Esr1*)35.10Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre/Esr1*)35.10Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• mice treated with tamoxifen staring at E10.5 exhibit focal pancreatic intraepithelial neoplasia
• mice not treated with tamoxifen develop focal PanIN that are not as numerous as in Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Krastm4Tyj/Krastm4Tyj Tg(Ipf1-cre/Esr1)35.10Dam mice
• acinar-ductal metaplasia precedes PanIN

endocrine/exocrine glands
increased pancreatic intraepithelial neoplasia incidence ( J:142188 )
• mice treated with tamoxifen staring at E10.5 exhibit focal pancreatic intraepithelial neoplasia
• mice not treated with tamoxifen develop focal PanIN that are not as numerous as in Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Krastm4Tyj/Krastm4Tyj Tg(Ipf1-cre/Esr1)35.10Dam mice
• acinar-ductal metaplasia precedes PanIN

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory