Phenotypes Associated with This Genotype

Genotype
MGI:3821735

• Allelic Composition: Ffar1^tm1Dgen/Ffar1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased amylin secretion ( J:141957 )

• attenuated amylin release when plasma free fatty acids become elevated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:141957 )

N • glucose tolerance is not improved over controls regardless of diet

abnormal circulating hormone level ( J:141957 )

• attenuated amylin release when plasma free fatty acids become elevated

• reduced GLP-1 levels when plasma free fatty acids become elevated

decreased circulating glucagon level ( J:141957 )

• when plasma free fatty acids become elevated

abnormal circulating insulin level ( J:141957 )

• the increase in plasma insulin resulting from elevated plasma free fatty acids is only half the increase seen in controls

abnormal triglyceride level ( J:141957 )

decreased circulating triglyceride level ( J:141957 )

• on a low fat diet

increased liver triglyceride level ( J:141957 )

• in the liver when on a low fat diet

behavior/neurological

increased food intake ( J:141957 )

• higher food intake than controls on a low fat diet

liver/biliary system

increased liver triglyceride level ( J:141957 )

• in the liver when on a low fat diet