Phenotypes Associated with This Genotype

Genotype
MGI:3821709

• Allelic Composition: Cbfb^tm1Itan/Cbfb^tm1Itan; Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:141144 )

• the number of HSA^hiCD69⁺ and HSA^hi TCRbeta^hi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• absolute numbers of CD4⁺ single positive mature thymocytes are reduced between 5-10 fold compared to controls

• however, the percentage of CD4⁺ T cells in peripheral lymph nodes is only slightly reduced

immune system

abnormal T cell differentiation ( J:141144 )

• the number of HSA^hiCD69⁺ and HSA^hi TCRbeta^hi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• absolute numbers of CD4⁺ single positive mature thymocytes are reduced between 5-10 fold compared to controls

• however, the percentage of CD4⁺ T cells in peripheral lymph nodes is only slightly reduced