Phenotypes Associated with This Genotype

Genotype
MGI:3820408

• Allelic Composition: Gata1^{tm5(GATA3)Sho}/Y
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:47295 )

♂ • mice die by E13.5

hematopoietic system

abnormal erythropoiesis ( J:47295 )

♂ • at E10.5, erythropoeisis is arrested at the proerythroblast stage and total cell numbers are 70% of wild-type

♂ • however, erythroid development can be partially rescued in cultured ES cells

anemia ( J:47295 )

♂

embryo

decreased embryo size ( J:47295 )

♂ • at E11.5 to E12.5

pale yolk sac ( J:47295 )

♂ • at E10.5, yolk sacs are pink instead of red as in wild-type mice

cardiovascular system

enlarged pericardium ( J:47295 )

♂ • at E11.5 to E12.5

growth/size/body

decreased embryo size ( J:47295 )

♂ • at E11.5 to E12.5

integument

pallor ( J:47295 )

♂ • at E11.5 to E12.5, mice are pale