Phenotypes Associated with This Genotype

Genotype
MGI:3820243

• Allelic Composition: Gtf2ird1^{Tg(Alb1-Myc)166.8Sst}/Gtf2ird1⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased liver weight ( J:34434 )

• through the first year of life, liver weight to body weight ratios are 1.3 to 1.5 times higher than the ratio in wild-type mice

• as neoplastic lesions develop in mice, the liver weight/body weight ratio increases significantly reaching values 2.5 times higher than controls at 16 months of age

abnormal hepatocyte morphology ( J:34434 )

• the first dysplastic hepatocytes are detected at 4 months of age but severe and wide-spread dysplasia only appear in males older than 1 year of age

increased liver tumor incidence ( J:101128 )

• mutants develop diffuse liver dysplasia by 6-9 months of age

increased hepatocellular carcinoma incidence ( J:101128 , J:34434 )

• 23% of mutants develop hepatocellular carcinoma by 12 months of age (J:101128)

• malignant neoplastic lesions appear between the 10 and 14 months of age, with 67% of males and 10% of females having carcinomas by 20 months of age (J:34434)

• the average tumor size in males is 1.0 x 1.4 cm (J:34434)

• these malignant lesions vary from well differentiated to poorly differentiated with the latter associated with intense mitotic activity, proliferation of neocapillaries, and large areas of hemorrhagic necrosis (J:34434)

• in late stage lesions, small ductular-like cells are found (J:34434)

increased liver adenoma incidence ( J:34434 )

• along with the development of hepatocellular carcinoma, non-malignant tumors also develop with a slightly higher incidence

neoplasm

increased liver tumor incidence ( J:101128 )

• mutants develop diffuse liver dysplasia by 6-9 months of age

increased hepatocellular carcinoma incidence ( J:101128 , J:34434 )

• 23% of mutants develop hepatocellular carcinoma by 12 months of age (J:101128)

• malignant neoplastic lesions appear between the 10 and 14 months of age, with 67% of males and 10% of females having carcinomas by 20 months of age (J:34434)

• the average tumor size in males is 1.0 x 1.4 cm (J:34434)

• these malignant lesions vary from well differentiated to poorly differentiated with the latter associated with intense mitotic activity, proliferation of neocapillaries, and large areas of hemorrhagic necrosis (J:34434)

• in late stage lesions, small ductular-like cells are found (J:34434)

increased liver adenoma incidence ( J:34434 )

• along with the development of hepatocellular carcinoma, non-malignant tumors also develop with a slightly higher incidence

growth/size/body

increased liver weight ( J:34434 )

• through the first year of life, liver weight to body weight ratios are 1.3 to 1.5 times higher than the ratio in wild-type mice

• as neoplastic lesions develop in mice, the liver weight/body weight ratio increases significantly reaching values 2.5 times higher than controls at 16 months of age