Phenotypes Associated with This Genotype

Genotype
MGI:3819957

• Allelic Composition: Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:141583 )

• 16% reduction in body mass

decreased body length ( J:141583 )

• 9% reduction in nose to anus body length

postnatal growth retardation ( J:141583 )

• modest growth retardation

enlarged spleen ( J:141583 )

hematopoietic system

abnormal definitive hematopoiesis ( J:141583 )

abnormal thrombopoiesis ( J:141583 )

• increased number of platelets in the peripheral circulation

abnormal bone marrow cell number ( J:141583 )

abnormal erythroblast number ( J:141583 )

• increased numbers of erythroblasts in early and mid maturation

• reduced apoptosis of basophilic and chromophilic erythroblasts

• proportional reduction of orthochromatic erythroblasts

abnormal erythrocyte morphology ( J:141583 )

• in the peripheral circulation

increased mean corpuscular volume ( J:141583 )

anisocytosis ( J:141583 )

poikilocytosis ( J:141583 )

polychromatophilia ( J:141583 )

reticulocytosis ( J:141583 )

• increased number of reticulocytes in peripheral blood

abnormal spleen morphology ( J:141583 )

enlarged spleen ( J:141583 )

increased spleen red pulp amount ( J:141583 )

• 2-3 fold increase in spleen erythroblast mass

immune system

abnormal thrombopoiesis ( J:141583 )

• increased number of platelets in the peripheral circulation

abnormal spleen morphology ( J:141583 )

enlarged spleen ( J:141583 )

increased spleen red pulp amount ( J:141583 )

• 2-3 fold increase in spleen erythroblast mass