Phenotypes Associated with This Genotype

Genotype
MGI:3819956

• Allelic Composition: Tg(Ggamma-T)15Cps/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:38778 )

♂ • mice develop prostate tumors between 16 and 24 weeks of age that lead to bladder obstruction and premature death

neoplasm

increased adrenal gland tumor incidence ( J:38778 )

♂ • in some mice

increased prostate gland tumor incidence ( J:38778 )

♂ • mice develop prostate tumors between 16 and 24 weeks of age that lead to bladder obstruction and premature death

♂ • tumors exhibit metastasis to the renal lymph nodes, adrenal glands and kidneys and micrometastasis to the lung, bone and thymus

♂ • 50% of mice develop prostate tumors between 16 and 20 weeks of age

♂ • 75% of mice 20 weeks or older develop prostate tumors

♂ • at 32 weeks, only 10% of mice are tumor free

♂ • prostate tumors develop on the ventral and dorsal lobes of the prostate

♂ • castrated mice develop prostate tumors at the same rate as intact mice

increased prostate intraepithelial neoplasia incidence ( J:38778 )

♂ • prostate tumors begin as multifocal intraepithelial neoplasia that progress rapidly to undifferentiated carcinoma

increased testis tumor incidence ( J:38778 )

♂ • some mice develop seminoma

increased hibernoma incidence ( J:38778 )

♂ • in some mice

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:38778 )

♂ • in some mice

increased prostate gland tumor incidence ( J:38778 )

♂ • mice develop prostate tumors between 16 and 24 weeks of age that lead to bladder obstruction and premature death

♂ • tumors exhibit metastasis to the renal lymph nodes, adrenal glands and kidneys and micrometastasis to the lung, bone and thymus

♂ • 50% of mice develop prostate tumors between 16 and 20 weeks of age

♂ • 75% of mice 20 weeks or older develop prostate tumors

♂ • at 32 weeks, only 10% of mice are tumor free

♂ • prostate tumors develop on the ventral and dorsal lobes of the prostate

♂ • castrated mice develop prostate tumors at the same rate as intact mice

increased prostate intraepithelial neoplasia incidence ( J:38778 )

♂ • prostate tumors begin as multifocal intraepithelial neoplasia that progress rapidly to undifferentiated carcinoma

increased testis tumor incidence ( J:38778 )

♂ • some mice develop seminoma

reproductive system

increased prostate gland tumor incidence ( J:38778 )

♂ • mice develop prostate tumors between 16 and 24 weeks of age that lead to bladder obstruction and premature death

♂ • tumors exhibit metastasis to the renal lymph nodes, adrenal glands and kidneys and micrometastasis to the lung, bone and thymus

♂ • 50% of mice develop prostate tumors between 16 and 20 weeks of age

♂ • 75% of mice 20 weeks or older develop prostate tumors

♂ • at 32 weeks, only 10% of mice are tumor free

♂ • prostate tumors develop on the ventral and dorsal lobes of the prostate

♂ • castrated mice develop prostate tumors at the same rate as intact mice

increased prostate intraepithelial neoplasia incidence ( J:38778 )

♂ • prostate tumors begin as multifocal intraepithelial neoplasia that progress rapidly to undifferentiated carcinoma

increased testis tumor incidence ( J:38778 )

♂ • some mice develop seminoma

renal/urinary system

urinary bladder obstruction ( J:38778 )

♂ • mice develop prostate tumors between 16 and 24 weeks of age that lead to bladder obstruction and premature death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:38778