Phenotypes Associated with This Genotype

Genotype
MGI:3819167

• Allelic Composition: Ret^tm1Giro/Ret^tm1Giro
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:141658 )

• mice die within 24 hours of birth

nervous system

nervous system phenotype ( J:141658 )

N • unlike in Ret^tm1Cos homozygotes, mice develop normal superior cervical ganglia

abnormal neuron differentiation ( J:141658 )

• cultures of neural crest cells destined to colonize the bowels exhibit reduced Ret+ cell expansion compared to wild-type cultures

abnormal enteric ganglia morphology ( J:141658 )

• mice exhibit defective ganglion formation along the entire bowel and stomach ganglions are absent or rare unlike in wild-type mice

renal/urinary system

absent kidney ( J:141658 )

cellular

abnormal neuron differentiation ( J:141658 )

• cultures of neural crest cells destined to colonize the bowels exhibit reduced Ret+ cell expansion compared to wild-type cultures