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Phenotypes Associated with This Genotype
Genotype
MGI:3818748
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (44 available); any Rag1 mutation (78 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (155 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• one mouse developed a stomach neoplasm

endocrine/exocrine glands
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

nervous system
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

mortality/aging
• median lifespan is 14 weeks compared to 7 weeks in Trp53tm1Brd Xrcc5tm1Dbr
• maximum lifespan is 20 weeks compared to 16 weeks in Trp53tm1Brd Xrcc5tm1Dbr

neoplasm
• one mouse developed a stomach neoplasm
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

respiratory system
• one-fifth of mice exhibit labored breathing prior to death compared to two-thirds of Rag1tm1Mom Trp53tm1Brd

behavior/neurological
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:141515


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory