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Phenotypes Associated with This Genotype
Genotype
MGI:3818698
Allelic
Composition
Taar1tm1Tdw/Taar1tm1Tdw
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taar1tm1Tdw mutation (0 available); any Taar1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no significant differences in anxiety or overall activity levels were found
• increase in the sensitivity to psychomotor-stimulating effects of amphetamine compared to wild-type mice
• baseline activity levels are similar to wild-type mice

nervous system
• increased striatal levels following exposure to amphetamine
• basal levels of dopamine are similar to wild-type mice
• overall lower percent prepulse inhibition of the acoustic startle response compared to wild-type controls
• baseline startle amplitude is similar to wild-type

homeostasis/metabolism
• increased striatal levels following exposure to amphetamine
• basal levels of dopamine are similar to wild-type mice
• increased striatal levels following exposure to amphetamine
• basal levels of norepinephrine are similar to wild-type mice
• amphetamine induced increases in dopamine and norepinephrine are enhanced compared to wild-type mice
• basal levels of dopamine and norepinephrine are similar to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:141501


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory