Mouse Genome Informatics
hm
    Taar1tm1Tdw/Taar1tm1Tdw
involves: 129S1/Sv * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• no significant differences in anxiety or overall activity levels were found (J:141501)
• increase in the sensitivity to psychomotor-stimulating effects of amphetamine compared to wild-type mice
• baseline activity levels are similar to wild-type mice

nervous system
• increased striatal levels following exposure to amphetamine
• basal levels of dopamine are similar to wild-type mice
• overall lower percent prepulse inhibition of the acoustic startle response compared to wild-type controls
• baseline startle amplitude is similar to wild-type

homeostasis/metabolism
• increased striatal levels following exposure to amphetamine
• basal levels of dopamine are similar to wild-type mice
• increased striatal levels following exposure to amphetamine
• basal levels of norepinephrine are similar to wild-type mice
• amphetamine induced increases in dopamine and norepinephrine are enhanced compared to wild-type mice
• basal levels of dopamine and norepinephrine are similar to wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:141501