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Phenotypes Associated with This Genotype
Genotype
MGI:3818417
Allelic
Composition
Hcsttm1.1Cln/Hcsttm1.1Cln
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcsttm1.1Cln mutation (0 available); any Hcst mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• embryo implantation sites are hypocellular compared to in wild-type mice
• at E10, the mesometrial lymphoid aggregate of pregnancy is enlarged compared to in wild-type mice
• however, decidual spiral artery develops normally
• at E10 and E12, the deciduas basalis is larger compared to in wild-type mice
• at E10 and E12 in the mesometrial lymphoid aggregate of pregnancy but not the deciduas basalis
• fewer mice become pregnant following mating compared to wild-type mice
• early post-implantation (E6 and E8) and midgestational (E10) fetal losses are greater than in wild-type mice

embryo
• embryo implantation sites are hypocellular compared to in wild-type mice
• at E10, the mesometrial lymphoid aggregate of pregnancy is enlarged compared to in wild-type mice
• however, decidual spiral artery develops normally
• at E10 and E12, the deciduas basalis is larger compared to in wild-type mice
• at E10 and E12 in the mesometrial lymphoid aggregate of pregnancy but not the deciduas basalis

immune system
• at E10 and E12 in the mesometrial lymphoid aggregate of pregnancy but not the deciduas basalis
• at E10 in the mesometrial lymphoid aggregate of pregnancy

hematopoietic system
• at E10 and E12 in the mesometrial lymphoid aggregate of pregnancy but not the deciduas basalis

endocrine/exocrine glands
• at E10 and E12 in the mesometrial lymphoid aggregate of pregnancy but not the deciduas basalis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory