Phenotypes Associated with This Genotype

Genotype
MGI:3818337

• Allelic Composition: Hcst^tm1.1Cln/Hcst^tm1.1Cln
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:80426 )

N • mice exhibit normal immune system development

decreased CD8-positive, alpha-beta T cell number ( J:80426 )

• following vaccination and re-challenge with RMAS.Raet1c cells, mice lack an IFN-gamma-secreting CD8+ T cell population that accumulates within tumors in similarly treated wild-type mice

impaired natural killer cell mediated cytotoxicity ( J:80426 )

• NK cell killing of RMAS.Raet1c or YAC cells is less efficient than that of wild-type mice

• NK cell surveillance exhibits reduced tumor rejection response following inoculation with RMAS tumor cells expressing Raet1c

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:80426 )

• following vaccination and re-challenge with RMAS.Raet1c cells, mice lack an IFN-gamma-secreting CD8+ T cell population that accumulates within tumors in similarly treated wild-type mice

impaired natural killer cell mediated cytotoxicity ( J:80426 )

• NK cell killing of RMAS.Raet1c or YAC cells is less efficient than that of wild-type mice

• NK cell surveillance exhibits reduced tumor rejection response following inoculation with RMAS tumor cells expressing Raet1c