Analysis Tools
immune system
|
• gamma-delta T cells found in lung epithelia preferentially express Vdelta4 instead of Vdelta1 as occurs in wild-type
• this Vdelta4 expression predominates at 4 weeks of age with irregular expression of the other Vdelta segments occurring less frequently than in wild-type mice
• the Vdelta recombination with J segments has limited diversity with 74% expressing a GGIR motif compared to just 23% in wild-type lung epithelial gamma delta T cells
• Vdelta usage of these lung epithelial gamma delta T cells becomes more diverse as mice age
|
|
• the number of gamma-delta T cells found in lung epithelia is about half that of wild-type at 4 weeks of age though no significant differences are observed in older mice (6-20 weeks of age)
|
hematopoietic system
|
• gamma-delta T cells found in lung epithelia preferentially express Vdelta4 instead of Vdelta1 as occurs in wild-type
• this Vdelta4 expression predominates at 4 weeks of age with irregular expression of the other Vdelta segments occurring less frequently than in wild-type mice
• the Vdelta recombination with J segments has limited diversity with 74% expressing a GGIR motif compared to just 23% in wild-type lung epithelial gamma delta T cells
• Vdelta usage of these lung epithelial gamma delta T cells becomes more diverse as mice age
|
|
• the number of gamma-delta T cells found in lung epithelia is about half that of wild-type at 4 weeks of age though no significant differences are observed in older mice (6-20 weeks of age)
|
