Phenotypes Associated with This Genotype

Genotype
MGI:3817490

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Isl1^tm2Sev/Isl1^tm2Sev; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:141110 )

• mice die within a few hours of birth

nervous system

abnormal sensory neuron innervation pattern ( J:141110 )

• cutaneous branch of the ventral ramus is absent in E14.5 embryos

• innervation of the distal limbs at E14.5 confirmed a nearly complete loss of fine cutaneous sensory fibers with only a single sensory branch innervating one side of digits 1, 2 and 5 in both the forelimb and hindlimb

abnormal trigeminal ganglion morphology ( J:141110 )

• there is an increased rate of apoptosis within the trigeminal ganglia of E11.5 and E12.5 embryos

abnormal dorsal root ganglion morphology ( J:141110 )

• the dorsal root ganglion (DRG) of E12.5 embryos do not express Isl1 protein

• TrkA⁺ neurons are lower in number starting at E12.5 and by E14.5 are less than one-third of what is found in controls

• TrkB⁺ neurons are also lower in number starting at E12.5 and are markedly reduced at E14.5 and birth

• TrkC⁺ neurons do not appear until E12.5, a delay of two days compared to controls

dorsal root ganglion hypoplasia ( J:141110 )

• the DRG of E14.5 embryos is markedly smaller than controls with a smaller number neurons found within the ganglion

• an increased rate of apoptosis is noted in the E12.5 DRG

behavior/neurological

decreased chemical nociceptive threshold ( J:141110 )

• mice have a reduced response to a mild noxious stimulus that was applied to the skin of the trunk or limbs