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Phenotypes Associated with This Genotype
Genotype
MGI:3817221
Allelic
Composition
Sox9tm1Gsr/Sox9+
Tg(Pdx1-cre)6Cvw/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm1Gsr mutation (2 available); any Sox9 mutation (12 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5
• at E18.5, the numbers of polypeptide producing cells are reduced compared to wild-type mice
• at E18.5, alpha cell mass is reduced 55% compared to in wild-type mice
• at E18.5, beta cell mass is reduced 57% compared to in wild-type mice
• however, beta cell differentiation is normal
• at E18.5, delta cell numbers are decreased compared to in wild-type mice
• mice exhibit islet hyperplasia
• the number of pancreatic endocrine progenitor cells is 2-fold less than in wild-type mice due to decreased cell proliferation of endocrine progenitor cells
• however, exocrine progenitor cells are normal in number and proliferation
• pancreatic glucagons is reduced 34.9% compared to in wild-type
• pancreatic insulin production is decreased 44% compared to in wild-type mice

digestive/alimentary system
N
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5

homeostasis/metabolism
• pancreatic glucagons is reduced 34.9% compared to in wild-type
• pancreatic insulin production is decreased 44% compared to in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Campomelic Dysplasia 114290 J:141017


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory