Mouse Genome Informatics
cn
    Sox9tm1Gsr/Sox9+
Tg(Pdx1-cre)6Cvw/0

involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
N
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5 (J:141017)
• at E18.5, the numbers of polypeptide producing cells are reduced compared to wild-type mice
• at E18.5, alpha cell mass is reduced 55% compared to in wild-type mice
• at E18.5, beta cell mass is reduced 57% compared to in wild-type mice
• however, beta cell differentiation is normal
• at E18.5, delta cell numbers are decreased compared to in wild-type mice
• mice exhibit islet hyperplasia
• the number of pancreatic endocrine progenitor cells is 2-fold less than in wild-type mice due to decreased cell proliferation of endocrine progenitor cells
• however, exocrine progenitor cells are normal in number and proliferation
• pancreatic glucagons is reduced 34.9% compared to in wild-type
• pancreatic insulin production is decreased 44% compared to in wild-type mice

digestive/alimentary system
N
• despite islet cell hypoplasia, pancreas size, weight, morphology and pancreatic exocrine differentiation are normal at E18.5 (J:141017)

homeostasis/metabolism
• pancreatic glucagons is reduced 34.9% compared to in wild-type
• pancreatic insulin production is decreased 44% compared to in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Campomelic Dysplasia 114290 J:141017