Phenotypes for Cd19 Gt(ROSA)26Sor Il10 MGI:3814893 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai}/Gt(ROSA)26Sor⁺ Il10^tm1Roer/Il10^tm1Roer
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Gt(ROSA)26Sor^{tm2(Cd74/MOG)Awai} mutation (0 available); any Gt(ROSA)26Sor mutation (1061 available)
Il10^tm1Roer mutation (1 available); any Il10 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:140751 )

• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:140751 )

• mice are resistant to direct and passive MOG-induced experimental autoimmune encephalomyelitis

hematopoietic system

abnormal B cell physiology ( J:140751 )

• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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