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Phenotypes Associated with This Genotype
Genotype
MGI:3814893
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Il10tm1Roer/Il10tm1Roer
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Gt(ROSA)26Sortm2(Cd74/MOG)Awai mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Il10tm1Roer mutation (1 available); any Il10 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:140751 )
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:140751 )
• mice are resistant to direct and passive MOG-induced experimental autoimmune encephalomyelitis

hematopoietic system
abnormal B cell physiology ( J:140751 )
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory