Phenotypes Associated with This Genotype

Genotype
MGI:3814824

• Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp; Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

gastrointestinal tract polyps ( J:134476 )

• 75% of tamoxifen-treated animals develop gastrointestinal polyposis by 11 months

• average size of polyps is comparable to that seen in double heterozygotes

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

neoplasm

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls