Phenotypes Associated with This Genotype

Genotype
MGI:3814821

• Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺; Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺
• Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:134476 )

• almost 50% of tamoxifen-treated animals die by 18 months from gastrointestinal obstruction (average lifespan 13.5 months); widespread gastrointestinal polyposis is found at time of necropsy

digestive/alimentary system

digestive/alimentary phenotype ( J:134476 )

N • with 2 intraperitoneal injections of tamoxifen at 6 weeks of age, no abnormalities are seen at 3 and 8 months of age

gastrointestinal tract polyps ( J:134476 )

• at 11 months, gastrointestinal tract polyps are observed in <60% of tamoxifen-treated animals

• average polyp size is smaller than in Stk11^tm1.2Rdp/+ mice at 11 months

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

• tumors are characterized by a smooth muscle core, abundant stroma and hyperplastic epithelia without dysplasia

intestinal obstruction ( J:134476 )

• at 11 months, mice present with severe gastrointestinal obstruction

neoplasm

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

• tumors are characterized by a smooth muscle core, abundant stroma and hyperplastic epithelia without dysplasia