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Phenotypes Associated with This Genotype
Genotype
MGI:3814819
Allelic
Composition
Ccl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic
Background
involves: 129 * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (8 available)
Cx3cr1tm1Zm mutation (1 available); any Cx3cr1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• beginning as early as 12 weeks of age,15% of mice exhibit neovascularization of the choroid unlike in wild-type mice
• choroidal neovascular vessels that penetrate Bruch membrane and enter the outer retinal layers are surrounded by hyperplastic retinal pigmented epithelium cells or atrophic retinal pigmented epithelium areas
• microglial infiltrates are observed in retinal lesions
• severity increases with age
• unlike in wild-type mice, vacuolation of the retinal pigmented epithelium (RPE) is observed
• mice exhibit a reduction in melanosomes and an increase in lipofuscin in the RPE unlike in wild-type mice
• unlike in wild-type mice, local hypopigmentation of the retina is observed
• in some areas with severity increasing with age
• by 6 to 9 weeks, mice exhibit drusen-like lesions with heterogeneous, round or domed-shaped, soft-bordered yellowish deposits within the subretina not observed in wild-type mice
• retinal depositions enlarge or flatten and become confluent with age
• beginning at 8 weeks of age, mice exhibit focal thickening in the Bruch membrane compared to wild-type mice

reproductive system
• average litter size is half of wild-type

nervous system
• severity increases with age

pigmentation
• 20% of mice exhibit patchy skin depigmentation on the face and upper extremities
• unlike in wild-type mice, vacuolation of the retinal pigmented epithelium (RPE) is observed
• mice exhibit a reduction in melanosomes and an increase in lipofuscin in the RPE unlike in wild-type mice
• unlike in wild-type mice, local hypopigmentation of the retina is observed
• in some areas with severity increasing with age

cardiovascular system
• beginning as early as 12 weeks of age,15% of mice exhibit neovascularization of the choroid unlike in wild-type mice
• choroidal neovascular vessels that penetrate Bruch membrane and enter the outer retinal layers are surrounded by hyperplastic retinal pigmented epithelium cells or atrophic retinal pigmented epithelium areas

integument
• 20% of mice exhibit patchy skin depigmentation on the face and upper extremities

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
age related macular degeneration DOID:10871 OMIM:PS603075
J:126935


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory