Phenotypes Associated with This Genotype

Genotype
MGI:3814730

• Allelic Composition: Tnk1^tm1Sksuf/Tnk1^tm1Sksuf
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:140639 )

• 43% (12 of 28) of mice develop spontaneous tumors with an average tumor latency of 17 months

• about 50% of mice synchronously developed more than 1 primary neoplasm

increased gastrointestinal tumor incidence ( J:140639 )

• the majority of tumors occur in the gastrointestinal tract

increased skin tumor incidence ( J:140639 )

• mice may also develop epithelial tumors of the skin

increased trichoepithelioma incidence ( J:140639 )

increased hepatocellular carcinoma incidence ( J:140639 )

increased lymphoma incidence ( J:140639 )

• 75% of mice with tumors had lymphoid tumors

increased B cell derived lymphoma incidence ( J:140639 )

• 7 of 28 mice developed malignant lymphomas of the small intestine and mesenteric lymph nodes

• lymphomas also developed in the spleen, thymus, salivary glands, and pancreas

• histologically lymphomas resembled lymphoblastic lymphomas

increased lung adenocarcinoma incidence ( J:140639 )

• mice may also develop lung adenocarcinomas

increased hemangiosarcoma incidence ( J:140639 )

• of the spleen

integument

increased skin tumor incidence ( J:140639 )

• mice may also develop epithelial tumors of the skin

increased trichoepithelioma incidence ( J:140639 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:140639 )

• the majority of tumors occur in the gastrointestinal tract

respiratory system

increased lung adenocarcinoma incidence ( J:140639 )

• mice may also develop lung adenocarcinomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:140639 )