Phenotypes Associated with This Genotype

Genotype
MGI:3814551

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Ikbkb^tm1Lex/Ikbkb^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal fibroblast migration ( J:159873 )

• following tamoxifen-treatment, mouse embryonic fibroblasts (MEFs) exhibit random migration in response to an HMGB1 gradient unlike wild-type cells

decreased fibroblast cell migration ( J:159873 )

• 30 to 60 minutes after exposure to HMGB1, tamoxifen-treated MEFs exhibit reduced migration velocity compared with wild-type mice

decreased fibroblast chemotaxis ( J:159873 )

• following tamoxifen-treatment, MEFs exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis in response to PDGF is normal and chemotaxis is rescued by over expression of Nfkb2