Phenotypes Associated with This Genotype

Genotype
MGI:3814412

• Allelic Composition: Trp53^tm1Glo/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:61683 )

• premature death is associated with early onset spontaneous tumor formation

neoplasm

increased metastatic potential ( J:61683 )

• mice develop highly metastatic tumors such as osteosarcomas and carcinomas with 17 of 51 mice exhibiting metastasis nodules in the lung, liver or both

• 69% of osteosarcomas metastasize whereas osteosarcomas in mice heterozygous for a Trp53 null allele rarely metastasize

• 40% of adenocarcinomas and squamous cell carcinomas metastasize

• however, fibrosarcomas do not exhibit metastasis

increased tumor incidence ( J:61683 )

• mice exhibit an increased rate of tumorigenesis and develop osteosarcomas, fibrosarcomas, angiosarcomas, lyposarcomas, adenocarcinomas, hepatocellular carcinomas, poorly differentiated carcinomas, squamous cell carcinomas, lymphoma and adenoma

• however, tumorigenesis is rarely accompanied by loss of heterozygosity

increased lymphoma incidence ( J:61683 )

• 16% of mice develop lymphomas compared to 25% and 32% of mice heterozygous for one of two Trp53 null allele

increased carcinoma incidence ( J:61683 )

• 29% of mice develop carcinomas compared to only 10% of mice heterozygous for a Trp53 null allele

increased squamous cell carcinoma incidence ( J:61683 )

increased sarcoma incidence ( J:61683 )

• in 54% of mice

increased fibrosarcoma incidence ( J:61683 )

increased hemangiosarcoma incidence ( J:61683 )

increased osteosarcoma incidence ( J:61683 )

skeleton

increased osteosarcoma incidence ( J:61683 )