Phenotypes Associated with This Genotype

Genotype
MGI:3814172

• Allelic Composition: Tcra^tm1Cgn/Tcra^tm1Cgn; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell morphology ( J:79298 )

• induction of cre expression at 6 weeks of age leads to loss of the T cell receptor complex (TCR)

• by 10 days after induction of cre, all T cells have lost normal expression of the TCR

• sensitive techniques reveal a very low level of TCR complex detectable on all T cells 10, 37 and 49 days after cre induction

abnormal CD4-positive, alpha beta T cell morphology ( J:79298 )

• the half-life decay of the CD4⁺ T cells after cre induction is 46 days compared to 78 days in controls

abnormal CD8-positive, alpha beta T cell morphology ( J:79298 )

• the half-life decay of the CD8⁺ T cells after cre induction is 16 days compared to 162 days in controls

abnormal memory T cell morphology ( J:79298 )

• after cre induction and loss of CD4 T cells, memory CD4 T cell numbers expand and fill the compartment

hematopoietic system

abnormal T cell morphology ( J:79298 )

• induction of cre expression at 6 weeks of age leads to loss of the T cell receptor complex (TCR)

• by 10 days after induction of cre, all T cells have lost normal expression of the TCR

• sensitive techniques reveal a very low level of TCR complex detectable on all T cells 10, 37 and 49 days after cre induction

abnormal CD4-positive, alpha beta T cell morphology ( J:79298 )

• the half-life decay of the CD4⁺ T cells after cre induction is 46 days compared to 78 days in controls

abnormal CD8-positive, alpha beta T cell morphology ( J:79298 )

• the half-life decay of the CD8⁺ T cells after cre induction is 16 days compared to 162 days in controls

abnormal memory T cell morphology ( J:79298 )

• after cre induction and loss of CD4 T cells, memory CD4 T cell numbers expand and fill the compartment