Phenotypes Associated with This Genotype

Genotype
MGI:3813610

• Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn; Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased transitional stage B cell number ( J:66840 )

• IgM^lowIgD^- CD25⁺ transitional B cells have increased rates of apoptosis

• B cells by largely fail to progress to the IgM⁺IgD⁺ CD25^- transitional B cell stage

arrested B cell differentiation ( J:66840 )

• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains

hematopoietic system

decreased transitional stage B cell number ( J:66840 )

• IgM^lowIgD^- CD25⁺ transitional B cells have increased rates of apoptosis

• B cells by largely fail to progress to the IgM⁺IgD⁺ CD25^- transitional B cell stage

arrested B cell differentiation ( J:66840 )

• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains