Phenotypes Associated with This Genotype

Genotype
MGI:3813607

• Allelic Composition: Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased transitional stage B cell number ( J:66840 )

• IgM^lowIgD^- CD25⁺ transitional B cells have increased rates of apoptosis

• B cells by largely fail to progress to the IgM⁺IgD⁺ CD25^- transitional B cell stage

increased pro-B cell number ( J:66840 )

• pro-B cell numbers are increased in the bone marrow

arrested B cell differentiation ( J:66840 )

• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains

decreased mature B cell number ( J:66840 )

• there is a 70-fold reduction in the number of recirculating mature B cells found in the bone marrow

• the number of mature B cells found in the spleen is reduced by about 50-fold

decreased pre-B cell number ( J:66840 )

• mice have a 25% decrease in IgM^-B220⁺CD43^-CD25⁺ pre-Bcells in the bone marrow

abnormal B cell activation ( J:66840 )

• production of antibodies to T cell dependent antigens is impaired

hematopoietic system

decreased transitional stage B cell number ( J:66840 )

• IgM^lowIgD^- CD25⁺ transitional B cells have increased rates of apoptosis

• B cells by largely fail to progress to the IgM⁺IgD⁺ CD25^- transitional B cell stage

increased pro-B cell number ( J:66840 )

• pro-B cell numbers are increased in the bone marrow

arrested B cell differentiation ( J:66840 )

• B cell development is largely arrested at the pre-BI stage due to a lack of positive selection for in-frame IgH chains

decreased mature B cell number ( J:66840 )

• there is a 70-fold reduction in the number of recirculating mature B cells found in the bone marrow

• the number of mature B cells found in the spleen is reduced by about 50-fold

decreased pre-B cell number ( J:66840 )

• mice have a 25% decrease in IgM^-B220⁺CD43^-CD25⁺ pre-Bcells in the bone marrow

abnormal B cell activation ( J:66840 )

• production of antibodies to T cell dependent antigens is impaired