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Phenotypes Associated with This Genotype
Genotype
MGI:3813587
Allelic
Composition
Kittm1.1Bsm/Kittm1.1Bsm
Genetic
Background
involves: 129S1/Sv * BALB/c * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1.1Bsm mutation (0 available); any Kit mutation (180 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• germ cells that fail to enter into meiosis at P10 undergo apoptosis and by P21 few germs cells remain in the seminiferous tubules

growth/size/body

reproductive system
N
• unlike in other Kit mutants, primordial germ cells survive, proliferate and migrate normally
• germ cells that fail to enter into meiosis at P10 undergo apoptosis and by P21 few germs cells remain in the seminiferous tubules
• mice exhibit ovarian tubule hyperplasia
• number of pre-antral follicle cells is reduced compared to in wild-type mice
• number of antral follicle cells is reduced compared to in wild-type mice
• follicle development is impaired at the cuboidal stages
• however, some oocytes undergo maturation
• at P10, germ cells fail to enter meiosis

immune system
• the number of mast cells in the peritoneal cavity is reduced 3.5-fold compared to in wild-type mice
• however, mice exhibit a normal number of mast cells in dorsal skin sections
• mast cells exhibit a 40% to 60% drop in apoptosis following treatment with steel factor/ mass cell growth factor (KL/Mgf) compared to similarly treated wild-type mice

homeostasis/metabolism
• 7-fold compared to in wild-type mice

hematopoietic system
N
• unlike in other Kit mutants, mice exhibit normal steady state hematopoiesis
• the number of mast cells in the peritoneal cavity is reduced 3.5-fold compared to in wild-type mice
• however, mice exhibit a normal number of mast cells in dorsal skin sections
• mast cells exhibit a 40% to 60% drop in apoptosis following treatment with steel factor/ mass cell growth factor (KL/Mgf) compared to similarly treated wild-type mice

pigmentation
N
• unlike in other Kit mutants, melanogenesis is normal

endocrine/exocrine glands
• mice exhibit ovarian tubule hyperplasia
• number of pre-antral follicle cells is reduced compared to in wild-type mice
• number of antral follicle cells is reduced compared to in wild-type mice
• follicle development is impaired at the cuboidal stages
• however, some oocytes undergo maturation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory