cellular
• germ cells that fail to enter into meiosis at P10 undergo apoptosis and by P21 few germs cells remain in the seminiferous tubules
|
growth/size/body
ovary cyst
(
J:61141
)
|
reproductive system
N |
• unlike in other Kit mutants, primordial germ cells survive, proliferate and migrate normally
|
• germ cells that fail to enter into meiosis at P10 undergo apoptosis and by P21 few germs cells remain in the seminiferous tubules
|
• mice exhibit ovarian tubule hyperplasia
|
• number of pre-antral follicle cells is reduced compared to in wild-type mice
|
• number of antral follicle cells is reduced compared to in wild-type mice
|
• follicle development is impaired at the cuboidal stages
• however, some oocytes undergo maturation
|
ovary cyst
(
J:61141
)
|
• at P10, germ cells fail to enter meiosis
|
immune system
• the number of mast cells in the peritoneal cavity is reduced 3.5-fold compared to in wild-type mice
• however, mice exhibit a normal number of mast cells in dorsal skin sections
|
• mast cells exhibit a 40% to 60% drop in apoptosis following treatment with steel factor/ mass cell growth factor (KL/Mgf) compared to similarly treated wild-type mice
|
homeostasis/metabolism
• 7-fold compared to in wild-type mice
|
hematopoietic system
N |
• unlike in other Kit mutants, mice exhibit normal steady state hematopoiesis
|
• the number of mast cells in the peritoneal cavity is reduced 3.5-fold compared to in wild-type mice
• however, mice exhibit a normal number of mast cells in dorsal skin sections
|
• mast cells exhibit a 40% to 60% drop in apoptosis following treatment with steel factor/ mass cell growth factor (KL/Mgf) compared to similarly treated wild-type mice
|
pigmentation
N |
• unlike in other Kit mutants, melanogenesis is normal
|
endocrine/exocrine glands
• mice exhibit ovarian tubule hyperplasia
|
• number of pre-antral follicle cells is reduced compared to in wild-type mice
|
• number of antral follicle cells is reduced compared to in wild-type mice
|
• follicle development is impaired at the cuboidal stages
• however, some oocytes undergo maturation
|
ovary cyst
(
J:61141
)
|