Mouse Genome Informatics
hm
    Nphp1tm1.1Hung/Nphp1tm1.1Hung
B6.Cg-Nphp1tm1.1Hung
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
N
• no abnormalities are found in the kidney (J:140205)

reproductive system
• testes weight is significantly lower than controls (80 mg vs. 94 mg in wild-type males) (J:140205)
• the few mature sperm found in the cauda epididymis showed morphological abnormalities, with less than 0.5% of total sperm being both motile and viable (J:140205)
• the flagellar membrane of the rare surviving spermatozoa found in the epididymides are usually ruptured, with the electron-dense microtubules of flagellar axonema dispersed and/or disorganized (J:140205)
• sperm counts in the testis and the cauda epididymis are significantly reduced by greater than 5-fold and greater than 20-fold, respectively (J:140205)
• there is a greater than 20-fold reduction in the number of viable sperm found in the cauda epididymis (J:140205)
• morphological abnormalities are first observed in the elongating spermatids of stages VIII-X (J:140205)
• many of the spermatids prematurely detach from Sertoli cells and degenerate before sloughing off into the lumen (J:140205)
• male mice are not capable of siring offspring (J:140205)

endocrine/exocrine glands
• testes weight is significantly lower than controls (80 mg vs. 94 mg in wild-type males) (J:140205)

cellular
• the flagellar membrane of the rare surviving spermatozoa found in the epididymides are usually ruptured, with the electron-dense microtubules of flagellar axonema dispersed and/or disorganized (J:140205)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Nephronophthisis 1; NPHP1 256100 J:140205