Phenotypes Associated with This Genotype

Genotype
MGI:3813263

• Allelic Composition: Myo5a^d-l/Myo5a^d-l
• Genetic Background: involves: C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:12978 )

opisthotonus ( J:12978 )

• arching is very extreme

impaired balance ( J:12978 )

• hardly able to walk by 12 days of age

• moves on its side and in circles trying to stand

impaired limb coordination ( J:12978 )

clonic seizures ( J:12978 )

• 9 day old mutants show slight convulsive limb movements

• by 12 days of age convulsions are marked with fore-limbs thrashing

• by 15 days of age convulsions are triggered when mouse is disturbed, overbalances and falls and occur while mouse regains upright posture

muscle

opisthotonus ( J:12978 )

• arching is very extreme

nervous system

clonic seizures ( J:12978 )

• 9 day old mutants show slight convulsive limb movements

• by 12 days of age convulsions are marked with fore-limbs thrashing

• by 15 days of age convulsions are triggered when mouse is disturbed, overbalances and falls and occur while mouse regains upright posture

pigmentation

diluted coat color ( J:12978 )

integument

diluted coat color ( J:12978 )