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Phenotypes Associated with This Genotype
Genotype
MGI:3812011
Allelic
Composition		 ApcMin/Apc+
Myctm1Jlc/Myc+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (156 available)
Myctm1Jlc mutation (0 available); any Myc mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:134087 )
N
• mice exhibit a life span of 291 days compared to 169 days in ApcMin heterozygotes

digestive/alimentary system
intestine polyps ( J:134087 )
• mice develop fewer and smaller polyps than in ApcMin heterozygotes
abnormal digestive system physiology ( J:134087 )
• cell proliferation in polyps is decreased compared to in ApcMin heterozygotes while levels of apoptosis are increased compared to in ApcMin heterozygotes and wild-type mice

hematopoietic system
hematopoietic system phenotype ( J:134087 )
N
• unlike in ApcMin heterozygotes, hematocrit levels and spleen size are normal
abnormal hematopoietic system morphology/development ( J:134087 )
• expression of angiogenic factors is decreased compared to in ApcMin heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory