Analysis Tools
cellular
|
• synchondrosal chondrocytes have reduced proliferative activity
|
craniofacial
|
• there is a population of apoptotic cells in the perichondrium of the presphenoid synchondrosis prior to its closure
|
|
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the sphenoid and presphenoid bones
• in contrast, the sphenooccipital synchondrosis remains patent, as in wild-type littermates
|
|
• adult mice show a mild longitudinal growth defect of the frontal bone
|
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• the sphenoid bones are much smaller
|
|
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the presphenoid bone
|
malocclusion
(
J:139970
)
|
• maxilla hypoplasia leads to an abnormal apposition of the incisors (class III malocclusion)
|
|
• adult mice show a mild longitudinal growth defect of the mandible
|
|
• adult pre-maxillary bones are severely reduced in length
|
|
• the growth of the upper jaw is profoundly retarded
|
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• adult maxillary bones are severely reduced in length
|
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• mineralization of the caudal nasal bone is markedly reduced
|
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• adult nasal bones are severely reduced in length
|
|
• dome-shaped skull vault noticeable by three weeks after birth
|
short snout
(
J:139970
)
|
• shortened and bent snouts are obvious three weeks after birth resulting from abnormal nasal bone growth in the rostral direction
|
skeleton
|
• synchondrosal chondrocytes have reduced proliferative activity
|
|
• there is a population of apoptotic cells in the perichondrium of the presphenoid synchondrosis prior to its closure
|
|
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the sphenoid and presphenoid bones
• in contrast, the sphenooccipital synchondrosis remains patent, as in wild-type littermates
|
|
• adult mice show a mild longitudinal growth defect of the frontal bone
|
|
• the sphenoid bones are much smaller
|
|
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the presphenoid bone
|
malocclusion
(
J:139970
)
|
• maxilla hypoplasia leads to an abnormal apposition of the incisors (class III malocclusion)
|
|
• adult mice show a mild longitudinal growth defect of the mandible
|
|
• adult pre-maxillary bones are severely reduced in length
|
|
• the growth of the upper jaw is profoundly retarded
|
|
• adult maxillary bones are severely reduced in length
|
|
• mineralization of the caudal nasal bone is markedly reduced
|
|
• adult nasal bones are severely reduced in length
|
|
• dome-shaped skull vault noticeable by three weeks after birth
|
|
• there is a population of apoptotic cells in the perichondrium of the presphenoid synchondrosis prior to its closure
|
|
• there is a delay in the intramembranous ossification of the facial and calvarial bones noted at 5 days after birth
|
growth/size/body
|
• adult mice show a mild longitudinal growth defect of the frontal bone
|
|
• early postnatal obliteration of the presphenoid synchondrosis results in the shortening of the presphenoid bone
|
malocclusion
(
J:139970
)
|
• maxilla hypoplasia leads to an abnormal apposition of the incisors (class III malocclusion)
|
|
• adult mice show a mild longitudinal growth defect of the mandible
|
|
• adult pre-maxillary bones are severely reduced in length
|
|
• the growth of the upper jaw is profoundly retarded
|
|
• adult maxillary bones are severely reduced in length
|
|
• mineralization of the caudal nasal bone is markedly reduced
|
|
• adult nasal bones are severely reduced in length
|
short snout
(
J:139970
)
|
• shortened and bent snouts are obvious three weeks after birth resulting from abnormal nasal bone growth in the rostral direction
|
respiratory system
|
• mineralization of the caudal nasal bone is markedly reduced
|
|
• adult nasal bones are severely reduced in length
|
