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Phenotypes Associated with This Genotype
Genotype
MGI:3811199
Allelic
Composition		 Mef2ctm1Jjs/Mef2ctm1Jjs
Mir223tm1Fcam/Mir223tm1Fcam
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Mef2ctm1Jjs mutation (1 available); any Mef2c mutation (33 available)
Mir223tm1Fcam mutation (1 available); any Mir223 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil differentiation ( J:140009 )
• neutrophils exhibit an unusual hypermature morphology characterized by nuclear hypersegmentation and blebbing
increased neutrophil cell number ( J:140009 )
• neutrophil numbers are normal in these mice unlike the increased numbers observed in Mirn223tm1Fcam homozygotes
abnormal neutrophil physiology ( J:140009 )
• neutorphils are hypersensitive to activating stimuli
• neutrophils have higher oxidative burst than controls upon low-dose PMA stimulation
• neutrophils display higher killing when co-cultured with Candida albicans

hematopoietic system
abnormal neutrophil differentiation ( J:140009 )
• neutrophils exhibit an unusual hypermature morphology characterized by nuclear hypersegmentation and blebbing
increased neutrophil cell number ( J:140009 )
• neutrophil numbers are normal in these mice unlike the increased numbers observed in Mirn223tm1Fcam homozygotes
abnormal neutrophil physiology ( J:140009 )
• neutorphils are hypersensitive to activating stimuli
• neutrophils have higher oxidative burst than controls upon low-dose PMA stimulation
• neutrophils display higher killing when co-cultured with Candida albicans

cellular
abnormal neutrophil differentiation ( J:140009 )
• neutrophils exhibit an unusual hypermature morphology characterized by nuclear hypersegmentation and blebbing

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory