Phenotypes Associated with This Genotype

Genotype
MGI:3811066

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Serpine1^tm1Mlg/Serpine1^tm1Mlg
• Genetic Background: B6.129-Serpine1^tm1Mlg Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:61287 )

• when fed a high fat Western diet for 6-30 weeks, mice develop atherosclerotic aortic lesions of the intimal and medial areas; incidence and severity are similar for Serpine1-deficient or transgenic Apoe-deficient genotypes

• lesions are somewhat larger than those observed on the Ldlr-deficient background

• cellular composition of lesions is similar among Serpine-deficient or transgenic, Apoe-deficient genotypes, or Apoe-deficient only mice; at early time points, a greater foam cell content is observed, with more prominent cholesterol clefts and necrotic areas evident with increasing age

• fibrin deposition is not significantly different among Serpine-deficient or transgenic, Apoe-deficient genotypes, or Apoe-deficient only mice

homeostasis/metabolism

increased circulating cholesterol level ( J:61287 )

• mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks)