Phenotypes Associated with This Genotype

Genotype
MGI:3810979

• Allelic Composition: Tg(CMV-Serpine1)1Dgi/0
• Genetic Background: involves: C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:31542 )

• bleomycin-induced increase in lung collagen content (determined from hydroxyproline content) is 3.2 fold greater than that in PBS-treated wild-type mice and significantly greater (1.9 fold greater) than that in bleomycin treated wild-type mice at 2 weeks post treatment

• lung fibrin deposition following bleomycin treatment is significantly increased compared to treated wild-type mice

pulmonary fibrosis ( J:31542 , J:140007 )

• mice exhibit increased susceptibility to pulmonary fibrosis following injury or intratracheal induction with bleomycin (J:140007)

neoplasm

neoplasm ( J:33232 )

N • no significant differences are observed compared to controls in terms of primary tumor size of footpad tumors induced by foot pad injection with tumor cells at 10, 17, or 21 days post-injection

N • after injection of melanoma cells, number of primary pulmonary metastases post-injection, or tumor burdens initiated by injections of increasing doses of cells do not significantly differ from wild-type controls

N • survival times after foot pad tumor removal are not significantly different among Serpine1-deficient, Serpine1-overexpressing transgenic, or wild-type mice