Phenotypes Associated with This Genotype

Genotype
MGI:3810739

• Allelic Composition: Pnmt^tm1(cre)Xbao/Pnmt^tm1(cre)Xbao
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:139932 )

N • plasma and urine levels of norepinephrine and dopamine are normal

N • adrenal levels of dopamine are normal

increased noradrenaline level ( J:139932 )

• adrenal norepinephrine is significantly increased

cardiovascular system

abnormal heart size ( J:139932 )

• end diastolic volume significantly reduced under restraint

• results in smaller stroke volume

thick ventricular wall ( J:139932 )

• ratio of left ventricular posterior wall thickness to left ventricular internal dimension is increased slightly in diastole

abnormal systemic arterial blood pressure ( J:139932 )

• hypotensive effect of autonomic input after "HEX" treatment is significantly diminished

hypertension ( J:139932 )

• become hypertensive during exercise relative to controls

• blood pressure is 11% higher than controls when exercising at 0.06 m/s