Pnmt^tm1(cre)Xbao
Targeted Allele Detail

Summary

• Symbol: Pnmt^tm1(cre)Xbao
• Name: phenylethanolamine-N-methyltransferase; targeted mutation 1, Xuping Bao
• MGI ID: MGI:3810658
• Gene: Pnmt Location: Chr11:98277449-98279006 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Pnmt^tm1(cre)Xbao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139932
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Pnmt^tm1(cre)Xbao expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pnmt (MGI:97724)

• Mutation details: The 1.1 kb segment between the ATG translation start site of exon 1 and a ClaI site in exon 3 was replaced with a cre recombinase cDNA and a PGK-neo selection cassette. Enzyme activity was absent in the adrenal, heart, and brain of homozygotes. (J:139932)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pnmt (mouse) Summary of all recombinase alleles driven by Pnmt. Alliance mouse Pnmt gene page

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnmt Mutation: 12 strains or lines available

References

• Original: J:139932 Bao X, et al., Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Circulation. 2007 Aug 28;116(9):1024-31
• All: 2 reference(s)