Analysis Tools
mortality/aging
|
• between 25% and 38% of pups are stillborn
|
liver/biliary system
| N |
• liver glycogen and albumin levels are comparable to control animals
|
|
• livers from neonates display a decrease in blood vessels
• fewer endothelial cells (ECs) are present in mutant liver vasculature; ECs are present but are less organized and more discontinuous than in controls
• fewer or collapsed-appearing sinusoidal channels are observed
• livers have a sparse and poorly developed sinusoidal network with numerous blood cells in the disrupted sinusoidal spaces
• parenchymal cells contain very few or no lipid droplets
• morphology of space of Disse is abnormal, showing large gaps between sinusoidal epithelial cells (SECs) and hepatocytes
• sinusoidal epithelium lacks fenestrations seen in normal livers
|
|
• hepatocytes are more scattered than in control livers and many are oddly shaped with fewer microvilli projections into the space of Disse
|
dark liver
(
J:100427
)
|
• livers of all newborn animals are dark red in appearance in contrast to pink color of control livers
|
|
• there is increase in red blood cells in liver due to defective circulation
• livers show a significant defect in lipoprotein uptake compared to controls
|
|
• 30 to 63% of newborns are jaundiced; suppression of transgenic Kdr by doxycycline treatement of dams during embryogenesis eliminates jaundice that is observed in untreated animals
|
cardiovascular system
|
• decreased number of blood vessels in liver
|
homeostasis/metabolism
| N |
• serum bilirubin levels are normal
|
