Phenotypes Associated with This Genotype

Genotype
MGI:3810293

• Allelic Composition: Dab1^tm1Cpr/Dab1^tm3.1Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:74239 )

N • mice exhibit a normal cerebellum and preplate splitting

abnormal neuronal migration ( J:74239 )

• late born neurons migrate into the marginal zone unlike in wild-type mice

abnormal cortical marginal zone morphology ( J:74239 )

• the neocortical marginal zone is thinner than in wild-type mice and crowded with small cells

abnormal hippocampus pyramidal cell layer ( J:74239 )

• mice exhibit a splitting of the stratum pyramidale in the CA1 region

• the ectopic pyramidal layer is closer to the hippocampal fissure, further from the alveus and becomes the main layer in the CA2 region

• however, the CA3 region and dentate gyrus develop normally

cellular

abnormal neuronal migration ( J:74239 )

• late born neurons migrate into the marginal zone unlike in wild-type mice