Phenotypes Associated with This Genotype

Genotype
MGI:3810062

• Allelic Composition: mt-Co1^m1Jiha; mt-Nd6^m1Dwa; mt-Nd6^m2Dwa
• Genetic Background: involves: C3H/An * C57BL/6J * M. m. domesticus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:132659 )

• mice with 14% mitochondria containing mt-Nd6^m1Dwa and 86% mitochondria containing mt-Nd6^m2Dwa in addition to all mitochondria containing mt-Co1^m1Jiha exhibit reduced complex IV activity compared to in wild-type mice

cardiovascular system

abnormal myocardial fiber physiology ( J:132659 )

• mice with 14% mitochondria containing mt-Nd6^m1Dwa and 86% mitochondria containing mt-Nd6^m2Dwa in addition to all mitochondria containing mt-Co1^m1Jiha exhibit mitochondrial proliferation, mitochondrial autophagy and myofibrillar degeneration unlike in wild-type mice

• however, the percentage of mitochondria with Nd6^m1Dwa did not alter the phenotype