mt-Nd6^m1Dwa
Spontaneous Allele Detail

Summary

• Symbol: mt-Nd6^m1Dwa
• Name: mitochondrially encoded NADH dehydrogenase 6; mutation 1, Douglas C Wallace
• MGI ID: MGI:3777241
• Synonyms: 13885insC
• Gene: mt-Nd6 Location: ChrMT:13552-14070 bp, - strand Genetic Position: ChrMT, Syntenic
• Alliance: mt-Nd6^m1Dwa page

Mutation origin

• Strain of Origin: C3H/An

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: This allele originated in an antimycin A-resistant mouse LA9 cell line with an insertion/duplication of a C in the CCCCCC sequence at ChrM:13885-13890 that created a frame shift at methionine codon 63 and resulted in premature termination at codon 79. (J:132659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mt-Nd6 Mutation: 0 strains or lines available

References

• Original: J:132659 Fan W, et al., A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. Science. 2008 Feb 15;319(5865):958-62
• All: 1 reference(s)