Phenotypes Associated with This Genotype

Genotype
MGI:3809817

• Allelic Composition: Cdh13^tm1Brns/Cdh13^tm1Brns; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:132759 )

• unlike in wild-type mice or Cdh13^tm1Brns homozygotes

mortality/aging

mortality/aging ( J:132759 )

N • mice exhibit an 18.5 day increase in average survival time compared to in Tg(MMTV-PyVT)634Mul mice

neoplasm

abnormal tumor vascularization ( J:132759 )

• tumors exhibit decreased neovscularization compared to in Tg(MMTV-PyVT)634Mul mice

increased mammary gland tumor incidence ( J:132759 )

• unlike in wild-type mice or Cdh13^tm1Brns homozygotes

increased metastatic potential ( J:132759 )

• all tumors exhibit pulmonary metastases unlike in Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:132759 )

• tumor endothelial cell density is reduced 31% and vessel branching is reduced 45% compared to in Tg(MMTV-PyVT)634Mul mice

• tumors exhibit a 6-fold increase in apoptosis and a 3-fold increase in oxygen-deprived areas compared to in Tg(MMTV-PyVT)634Mul mice

• tumors exhibit decreased neovscularization compared to in Tg(MMTV-PyVT)634Mul mice

• tumor incidence, diversity and differentiation are reduced compared to in Tg(MMTV-PyVT)634Mul mice

• when mice were transplanted with Tg(MMTV-PyVT)634Mul mice or Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul tumors, the weight of the tumors is reduced compared to when they are transplanted into wild-type mice

• adiponectin staining of tumors is reduced compared to in Tg(MMTV-PyVT)634Mul mice

• tumor proliferation is the same as in Tg(MMTV-PyVT)634Mul mice

decreased tumor growth/size ( J:132759 )

• mice exhibit a 3-fold reduction in the area covered by mammary tumors compared to in Tg(MMTV-PyVT)634Mul mice

decreased incidence of induced tumors ( J:132759 )

• mice exhibit a 10 day delay in mammary tumor onset, a 3-fold reduction in the area covered by mammary tumors and an 18.5 day increase in average survival time compared to in Tg(MMTV-PyVT)634Mul mice

integument

increased mammary gland tumor incidence ( J:132759 )

• unlike in wild-type mice or Cdh13^tm1Brns homozygotes

cardiovascular system

abnormal tumor vascularization ( J:132759 )

• tumors exhibit decreased neovscularization compared to in Tg(MMTV-PyVT)634Mul mice