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Phenotypes Associated with This Genotype
Genotype
MGI:3809794
Allelic
Composition		 Tg(IghMyc)22Bri/0
Xiaptm1Hs/Xiaptm1Hs
Genetic
Background		 B6.Cg-Xiaptm1Hs Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (2 available)
Xiaptm1Hs mutation (1 available); any Xiap mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:138979 )
N
• mice exhibit increased survival compared to Tg(IghMyc)22Bri mice

immune system
increased B cell apoptosis ( J:138979 )
• compared to in Tg(IghMyc)22Bri mice
decreased B cell proliferation ( J:138979 )
• compared to in Tg(IghMyc)22Bri mice
decreased leukocyte cell number ( J:138979 )
• peripheral white blood counts are lower than in Tg(IghMyc)22Bri mice that develop leukemia

hematopoietic system
increased B cell apoptosis ( J:138979 )
• compared to in Tg(IghMyc)22Bri mice
decreased B cell proliferation ( J:138979 )
• compared to in Tg(IghMyc)22Bri mice
decreased leukocyte cell number ( J:138979 )
• peripheral white blood counts are lower than in Tg(IghMyc)22Bri mice that develop leukemia

cellular
increased B cell apoptosis ( J:138979 )
• compared to in Tg(IghMyc)22Bri mice
decreased B cell proliferation ( J:138979 )
• compared to in Tg(IghMyc)22Bri mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory