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Phenotypes Associated with This Genotype
Genotype
MGI:3809773
Allelic
Composition
Psmc1tm1Maye/Psmc1tm1Maye
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-cre)1Lin/0
Genetic
Background
involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmc1tm1Maye mutation (0 available); any Psmc1 mutation (19 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-cre)1Lin mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at 3-4 months of age

growth/size/body
• subtle growth retardation starting 5 weeks of age and becoming statistically significant by 8 weeks

behavior/neurological
• obvious spatial learning deficits in the Morris water maze at 8 weeks
• lack interest in locating food at 3-4 months of age
• significantly more anxious in open-field analysis at 6 weeks

nervous system
• expansion of the ventricular cavities accompanying atrophy of the forebrain
• extensive neuronal loss by 8 weeks
• significant progressive atrophy of the forebrain
• extensive gliosis as a result of the neuronal damage
• numerous eosinophilic intraneuronal paranuclear inclusions, containing ubiquitin, alpha-synuclein, and p62, similar to Lewy bodies
• neurodegeneration was evident in neurons expressing Tg(Camk2a-tTA)1Mmay in forebrain, hippocampus, striatum, and amygdala

cellular


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory