Psmc1^tm1Maye
Targeted Allele Detail

Summary

• Symbol: Psmc1^tm1Maye
• Name: protease (prosome, macropain) 26S subunit, ATPase 1; targeted mutation 1, R John Mayer
• MGI ID: MGI:3809769
• Synonyms: Psmc1^fl, Rpt2^flox
• Gene: Psmc1 Location: Chr12:100076461-100089623 bp, + strand Genetic Position: Chr12, 50.43 cM
• Alliance: Psmc1^tm1Maye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked neo cassette and a loxP site were introduced by homologous recombination into introns 1 and 3 respectively. The neo cassette was excised by transient expression of cre recombinase in vitro leaving exons 2 and 3 floxed. (J:138991)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmc1 Mutation: 23 strains or lines available

References

• Original: J:138991 Bedford L, et al., Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci. 2008 Aug 13;28(33):8189-98
• All: 10 reference(s)