Phenotypes Associated with This Genotype

Genotype
MGI:3809714

• Allelic Composition: Rgs5^tm1.1Rgan/Rgs5^tm1.1Rgan; Tg(RIP1-Tag)5Dh/0
• Genetic Background: C3.Cg-Rgs5^tm1.1Rgan Tg(RIP1-Tag)5Dh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased insulinoma incidence ( J:136259 )

• mice exhibit increased tumor growth with increased tumor burden and premature death due to hypoglycemia compared to wild-type mice

• survival following tumor development can be increased with pre-activated anti-TAG T cells or vaccination with Tag and CpG-ODN 1668 compared to in similarly treated in Tg(RIP1-Tag)5Dh mice

mortality/aging

premature death ( J:136259 )

• mice exhibit premature death due to hypoglycemia

• survival following tumor development can be increased with pre-activated anti-TAG T cells or vaccination with Tag and CpG-ODN 1668 compared to in similarly treated in Tg(RIP1-Tag)5Dh mice

decreased tumor-free survival time ( J:136259 )

neoplasm

increased insulinoma incidence ( J:136259 )

• mice exhibit increased tumor growth with increased tumor burden and premature death due to hypoglycemia compared to wild-type mice

• survival following tumor development can be increased with pre-activated anti-TAG T cells or vaccination with Tag and CpG-ODN 1668 compared to in similarly treated in Tg(RIP1-Tag)5Dh mice

abnormal tumor morphology ( J:136259 )

• tumor vasculature is normalized unlike in Tg(RIP1-Tag)5Dh mice with fewer enlarged vessels

• tumors exhibit more mature pericytes, increased oxygen supply and 50% reduced permeability compared to in Tg(RIP1-Tag)5Dh mice

• in adoptive transfer experiments, tumors exhibit an increase in spontaneous T cell infiltrate compared to in Tg(RIP1-Tag)5Dh mice

• T cell infiltrate into tumors is increased following vaccination unlike in Tg(RIP1-Tag)5Dh mice

• AG104A fibrosarcomas transferred into mice exhibit increased growth, increased vasculature, decreased vessel permeability and reduced hypoxia compared to tumors transferred into Tg(RIP1-Tag)5Dh mice

increased tumor growth/size ( J:136259 )

• AG104A fibrosarcomas transferred into mice exhibit increased growth compared to tumors transferred into Tg(RIP1-Tag)5Dh mice

preneoplasia ( J:136259 )

• mice exhibit early tumorigenesis with comparable numbers of angiogenic islets per mouse as in Tg(RIP1-Tag)5Dh mice

homeostasis/metabolism

hypoglycemia ( J:136259 )

• mice exhibit premature death due to hypoglycemia

edema ( J:136259 )

• following cerebral ischemia, mice exhibit reduced edema compared to in Tg(RIP1-Tag)5Dh mice