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Phenotypes Associated with This Genotype
Genotype
MGI:3809542
Allelic
Composition		 Pdx1tm1Macd/Pdx1+
Tg(tetO-Neurog3)8Ggu/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Macd mutation (1 available); any Pdx1 mutation (35 available)
Tg(tetO-Neurog3)8Ggu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreas development ( J:136131 )
• epithelial to mesenchyme transition is induced in the pancreas
• mice exhibit precocious endocrine differentiation, converting nearly all pancreatic cells to glucagon producing cells after E11.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory