Phenotypes Associated with This Genotype

Genotype
MGI:3809534

• Allelic Composition: Del(17)T^hp/+
• Genetic Background: involves: AKR/J * C57BL/Gr * CBA/Gr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

polydactyly ( J:31524 )

• on the hind feet of embryos inheriting the T^hp allele from their mother

abnormal tail development ( J:31524 )

• at E12 the base of the tail is constricted; the thickness of the tail itself varies

• at E13 the tail distal to the constriction is thinned

• by E14 the tail is thinned to a filament which often drops off resulting in a blunt-ended tail or tail rudiment

short tail ( J:31524 )

• shortened by varying amounts

• the only abnormality seen in older embryos

kinked tail ( J:31524 )

• varying degrees

thick tail ( J:31524 )

• degree of thickness varies

reproductive system

decreased litter size ( J:31524 )

• litters from carrier males and normal females are reduced compared to normal; litters from matings of carrier females and normal males are even smaller in size

homeostasis/metabolism

edema ( J:31524 )

• embryos inheriting the T^hp allele from their mother are edematous

growth/size/body

slow postnatal weight gain ( J:31524 )

• characteristic of mice inheriting the T^hp allele from their father

embryo

abnormal neural tube morphology ( J:31524 )

• at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother

abnormal neural tube closure ( J:31524 )

open neural tube ( J:31524 )

• characteristic of some E10 embryos inheriting the T^hp allele from their father

spina bifida ( J:31524 )

• occurs at a low frequency among embryos inheriting the T^hp allele from their mother

abnormal notochord morphology ( J:31524 )

• at E10 the notochord in the trunk is poorly differentiated and characteristic of embryos inheriting the T^hp allele from their father

• at E10 the notochord in the tail may be absent, swollen, or duplicated in embryos inheriting the T^hp allele from their father

absent notochord ( J:31524 )

• at E10 the tail notochord may be absent in embryos inheriting the T^hp allele from their father

cardiovascular system

distended pericardium ( J:31524 )

• inflation of the pericardium is seen in embryos inheriting the T^hp allele from their mother

nervous system

abnormal neural tube morphology ( J:31524 )

• at E10 the neural tube of the tail region is often doubled or tripled in embryos inheriting the T^hp allele from their mother

abnormal neural tube closure ( J:31524 )

open neural tube ( J:31524 )

• characteristic of some E10 embryos inheriting the T^hp allele from their father

spina bifida ( J:31524 )

• occurs at a low frequency among embryos inheriting the T^hp allele from their mother

exencephaly ( J:31524 )

• occurs in low frequency among embryos inheriting the T^hp allele from their mother

skeleton

abnormal vertebral column morphology ( J:31524 )

• may end abruptly before or at the level of the second sacral vertebra

abnormal cervical vertebrae morphology ( J:31524 )

• characteristic of embryos inheriting the T^hp allele from their father

• one or more may be incomplete dorsally

abnormal cervical atlas morphology ( J:31524 )

• characteristic of embryos inheriting the T^hp allele from their father

• frequently incomplete dorsally

abnormal cervical axis morphology ( J:31524 )

• characteristic of embryos inheriting the T^hp allele from their father

• frequently incomplete dorsally

abnormal sacral vertebrae morphology ( J:31524 )

short vertebral column ( J:31524 )

cellular

maternal effect ( J:31524 )

• heterozygous offspring from carrier females and normal males are edematous and die before or at birth