Phenotypes Associated with This Genotype

Genotype
MGI:3809478

• Allelic Composition: Cebpa^{tm1.1(Cebpb)Ylee}/Cebpa^{tm1.1(Cebpb)Ylee}
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:77646 )

• brown adipose tissue is more vacuolated than in wild-type mice

increased brown adipose tissue amount ( J:77646 )

abnormal fat cell morphology ( J:77646 )

• adipocytes are reduced in size and exhibit reduced lipid accumulation compared to in wild-type mice

abnormal white adipose tissue morphology ( J:77646 )

• white adipose tissue is reduced and yellow compared to in wild-type mice

decreased white adipose tissue amount ( J:77646 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:77646 )

N • unlike in Cebpa null mice, normal serum glucose and lipid levels

decreased circulating leptin level ( J:77646 )

behavior/neurological

increased food intake ( J:77646 )

• mice consume 9% more food than wild-type mice

hematopoietic system

abnormal hematopoietic system physiology ( J:77646 )

• mice exhibit decreased hemolytic activity compared to wild-type mice

growth/size/body

growth/size/body region phenotype ( J:77646 )

N • unlike in Cebpa null mice, growth is normal

immune system

immune system phenotype ( J:77646 )

N • unlike in Cebpa null mice, acute phase response to LPS is normal

reproductive system

reproductive system phenotype ( J:77646 )

N • mice are fertile