Phenotypes Associated with This Genotype

Genotype
MGI:3809476

• Allelic Composition: Prkdc^scid/Prkdc^scid; Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
• Genetic Background: NOD.Cg-Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz Prkdc^scid/Gck

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:126700 )

• these mice live significantly longer than NOD/scid mice that do not carry the transgene

• the mean lifespan for these mice is 420.5 days compared to 247.6 days for NOD/scid controls

• controls die of thymic or splenic lymphoma

immune system

absent T cells ( J:126700 )

• T cells are absent in these mice

abnormal professional antigen presenting cell morphology ( J:126700 )

• 10-12% of peripheral blood mononuclear cells express the chimeric MHC complex

hematopoietic system

absent T cells ( J:126700 )

• T cells are absent in these mice