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Phenotypes Associated with This Genotype
Genotype
MGI:3809472
Allelic
Composition
Cebpatm8.1Nerl/Cebpatm8.1Nerl
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm8.1Nerl mutation (0 available); any Cebpa mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• mice die after 9 to 14 months
• fewer than expected mice survive to weaning

hematopoietic system
• mice exhibit bone marrow failure with the replacement of normal hematopoietic cells with Mac1+Gr1lo and high myeloid blasts counts
• bone marrow myeloid progenitor cells exhibit an increase in proliferative capacity compared to in wild-type mice
• myeloid progenitor cells exhibit increased self-renewal capacity compared to wild-type cells
• mice exhibit ectopic myelopoiesis
• in late stages
• in late stages, mice exhibit decreased leukocyte counts
• at 2 months of age, peripheral blood contains lower numbers of myeloid cells compared to in wild-type mice
• mice exhibit a progressive block in granulocyte differentiation at an intermediate stage hyperproliferation
• at 2 months of age, mice exhibit neutropenic bone marrow, low numbers of Mac1+Gr1+ cells and few granulocytes
• at 2 months of age

neoplasm
• mice develop acute myeloid leukemia
• normal hematopoiesis is displaced by malignant myeloid cells
• malignant cells are transplantable in the absence of phenotypic hematopoietic stem cells
• the only karyotype abnormality observed in tumor cells is the loss of the Y chromosome

liver/biliary system
• mice exhibit massive hematopoietic infiltrates with remaining hepatocytes scattered compared to in wild-type mice

homeostasis/metabolism
• at birth

immune system
• in late stages, mice exhibit decreased leukocyte counts
• at 2 months of age, peripheral blood contains lower numbers of myeloid cells compared to in wild-type mice
• mice exhibit a progressive block in granulocyte differentiation at an intermediate stage hyperproliferation
• at 2 months of age, mice exhibit neutropenic bone marrow, low numbers of Mac1+Gr1+ cells and few granulocytes
• at 2 months of age
• mice exhibit massive hematopoietic infiltrates with remaining hepatocytes scattered compared to in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:136134


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory